Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum
2001 (English)In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 101, no 1-3, 87-91 p.Article in journal (Refereed) Published
Objective: The purpose of this study was to investigate the effects of progesterone and the most commonly prescribed synthetic progestogen, norethisterone, on regional immune-like reactivity of neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA) and neurotensin (NT) in brains of female ovariectomized estradiol-substituted rats.
Results: Norethisterone+estradiol-treated rats had 44% lower SP levels compared with estradiol-only-treated in frontal cortex and 20% lower NKA levels in comparison with progesterone+estradiol-treated in frontal cortex. Progesterone+estradiol-treated rats had 66% lower SP levels in striatum in comparison with both estradiol-only-treated and norethisterone+estradiol-treated. No significant results were found for NPY and NT.
Conclusion: Progesterone and the synthetic progestogen, norethisterone, have different effects on SP- and NKA-like immunoreactivity in rat cortex and striatum.
The effects of NET on SP- and NKA-like immunoreactivity in frontal cortex may contribute to the mood effects ascribed to this progestogen in clinical usage.
Place, publisher, year, edition, pages
2001. Vol. 101, no 1-3, 87-91 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-25336DOI: 10.1016/S0167-0115(01)00265-8Local ID: 9778OAI: oai:DiVA.org:liu-25336DiVA: diva2:245664