liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Apoptosis and Bcl-2 expression in relation to age, tumor characteristics and prognosis in breast cancer
Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
1999 (English)In: International Journal of Biological Markers, ISSN 0393-6155, Vol. 14, no 2, 84-91 p.Article in journal (Refereed) Published
Abstract [en]

The extent of apoptosis and the expression of Bcl-2 was investigated in tumor samples from 165 women who underwent surgery for primary breast carcinoma between 1989 and 1990 in South-East Sweden. Apoptosis was assessed by a DNA fragmentation assay for flow cytometry. Bcl-2 protein expression was analyzed with immunocytochemistry. Bcl-2 immunoreactivity correlated with estrogen receptor (ER) and progesterone receptor (PgR) positivity and was inversely correlated with p53 accumulation. Apoptosis increased with patient age and a high degree of apoptosis was negatively associated with Bcl-2 immunostaining. Apoptosis showed no significant correlation with any of the other variables studied, including prognosis. The group with Bcl-2-positive tumors tended to have a lower risk of distant recurrence than others, but the association of Bcl-2 with recurrence was different in groups divided by ER and PgR status. Whereas Bcl-2 positivity indicated a low recurrence rate among PgR-negative patients, in the PgR-positive group, those with Bcl-2-positive tumors showed a non significantly higher recurrence rate than Bcl-2-negative cases. In the PgR-positive group, Bcl-2-positive tumors also appeared more frequently to be lymph node positive and DNA aneuploid. The results suggest that hormone receptor status is of importance for the prognostic role of Bcl-2. Likewise, patient age merits consideration when apoptosis is studied in human cancer.

Place, publisher, year, edition, pages
1999. Vol. 14, no 2, 84-91 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25386PubMedID: 10399627Local ID: 9829OAI: diva2:245715
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2013-01-16

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Stål, Olle
By organisation
OncologyFaculty of Health Sciences
In the same journal
International Journal of Biological Markers
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link