NGF modulates CGRP synthesis in human B-lymphocytes: A possible anti-inflammatory action of NGF?
2002 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, Vol. 123, no 1-2, 58-65 p.Article in journal (Refereed) Published
We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction in CGRP expression in both resting and activated B-cells. Thus, NGF appears to directly affect the synthesis of CGRP in B-cells as in sensory neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can influence the intensity and duration of the immune response. ⌐ 2002 Elsevier Science B.V. All rights reserved.
Place, publisher, year, edition, pages
2002. Vol. 123, no 1-2, 58-65 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-25430DOI: 10.1016/S0165-5728(01)00475-1Local ID: 9876OAI: oai:DiVA.org:liu-25430DiVA: diva2:245759