liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
NGF modulates CGRP synthesis in human B-lymphocytes: A possible anti-inflammatory action of NGF?
Show others and affiliations
2002 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, Vol. 123, no 1-2, 58-65 p.Article in journal (Refereed) Published
Abstract [en]

We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction in CGRP expression in both resting and activated B-cells. Thus, NGF appears to directly affect the synthesis of CGRP in B-cells as in sensory neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can influence the intensity and duration of the immune response. ⌐ 2002 Elsevier Science B.V. All rights reserved.

Place, publisher, year, edition, pages
2002. Vol. 123, no 1-2, 58-65 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25430DOI: 10.1016/S0165-5728(01)00475-1Local ID: 9876OAI: diva2:245759
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Theodorsson, Elvar
By organisation
Faculty of Health SciencesClinical ChemistryDepartment of Clinical Chemistry
In the same journal
Journal of Neuroimmunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link