On the prognosis and treatment of early stage endometrial carcinoma: Studies with special reference to uterine papillary serous carcinoma
1992 (English)Doctoral thesis, comprehensive summary (Other academic)
The prognosis and therapy in the subgroup of endometrial malignancies called Uterine Papillary Serous Carcinoma (UPSC) was investigated. This entity constitutes about 6-8 % of all endometrial carcinomas clinical stage I but, as has been shown here, accounts for one third of the cancer mortality in the early stages of endometrial carcinoma.
-The prognostic significance of nuclear atypia, FIGO grade and age was determined in patients with clinical stage 1-11 Uterine Papillary Serous Carcinoma.
-DNA-index and S-phase fraction, determined by flow cytometry on formalin-fixed, paraffin-embedded endometrial curettage material was evaluated in relation to nuclear atypia, FIGO grade and age in early stage endometrial carcinoma.
-A new method of minimizing the dilution of non-epithelial cells in the malignant curettage material when performing flow cytometry was developed.
-The survival and pattern of metastasis in a population-based patient material was investigated -The effects on survival of a new aggressive treatment regimen was assessed.
The results show that: Patients with uterine papillary serous carcinoma have a much worse prognosis than do patients with ordinary endometrial carcinoma.
DNA ploidy and S-phaseratederived from flow cytometryperformed on disintegrated, previously paraffinembedded, endometrial curettings are important prognostic factors.
It is possible to exclude contaminating non-epithelial cells from the DNA analysis by the use of an anticytokeratin antibody, Patients with uterine papillary serous carcinoma clinical stage I have a significantly higher risk of recurrence than patients with non-UPSC. The localisation of the recurrences among the UPSC patients is more similar to that of serous papillary ovarian carcinoma than that of ordinary adenocarcinoma of the endometrium. A primary treatment ofUPSC with a more extensive surgery, adjuvant external radiation and platinum-based chemotherapy seems to improve the outcome.
Place, publisher, year, edition, pages
Linköping: Linköpings universitet , 1992. , 39 p.
Linköping University Medical Dissertations, ISSN 0345-0082 ; 359
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-25704Local ID: 10080ISBN: 91-7870-646-7OAI: oai:DiVA.org:liu-25704DiVA: diva2:246252
1992-05-15, Onkologiska institutionens föreläsningssal, Universitetssjukhuset, Linköping, 09:00 (Swedish)
Sorbe, Bengt, Docent
Papers, included in the Ph.D. thesis, are not registered and included in the posts from 1999 and backwards.2009-10-082009-10-082012-07-19Bibliographically approved