liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Localization of the Yersinia PTPase to focal complexes is an important virulence mechanism
Department of Cell and Molecular Biology, Umeå University, Umeå, Sweden.
Department of Cell and Molecular Biology, Umeå University, Umeå, Sweden.
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
Department of Microbiology, National Defense Research Establishment, Umeå, Sweden.
Show others and affiliations
1999 (English)In: Molecular Microbiology, ISSN 0950-382X, E-ISSN 1365-2958, Vol. 33, no 4, 828-838 p.Article in journal (Refereed) Published
Abstract [en]

The protein tyrosine phosphatase YopH, produced by the pathogen Yersinia pseudotuberculosis, is an essential virulence determinant involved in antiphagocytosis. Upon infection, YopH is translocated into the target cell, where it recognizes focal complexes. Genetic analysis revealed that YopH harbours a region that is responsible for specific localization of this PTPase to focal complexes in HeLa cells and professional phagocytes. This region is a prerequisite for blocking an immediate–early Yersinia-induced signal within target cells. The region is also essential for antiphagocytosis and virulence, illustrating the biological significance of localization of YopH to focal complexes during Yersinia infection. These results also indicate that focal complexes play a role in the general phagocytic process.

Place, publisher, year, edition, pages
1999. Vol. 33, no 4, 828-838 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25764DOI: 10.1046/j.1365-2958.1999.01529.xLocal ID: 10198OAI: diva2:246312
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-08-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Medical MicrobiologyFaculty of Health Sciences
In the same journal
Molecular Microbiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 22 hits
ReferencesLink to record
Permanent link

Direct link