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Multiple sclerosis and ionizing radiation.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine. Östergötlands Läns Landsting, Pain and Occupational Centre, Occupational and Environmental Medicine Centre.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine.
2001 (English)In: Neuroepidemiology, ISSN 0251-5350, E-ISSN 1423-0208, Vol. 120, 175-178 p.Article in journal (Refereed) Published
Abstract [en]

The etiology of multiple sclerosis (MS) may involve exposure to infectious, chemical or physical agents damaging the blood-brain barrier and an autoimmune reaction against myelin breakdown products. Here we report a pooled analysis of 174 MS cases and 815 population controls from two case-control studies with regard to such a potentially damaging exposure, namely X-ray examinations, radiological work and treatment with ionizing radiation. Exposure was assessed by questionnaires to the subjects. We obtained odds ratios of 4.4 (95% confidence interval, CI, 1.6-11.6) and 1.8 (95% CI 1.2-2.6) for radiological work and X-ray examinations, respectively, 5 cases, but no controls, in one of the studies had been treated with ionizing radiation. Our data and some other observations reported in the literature suggest a contributory role for ionizing radiation to the development of MS in some cases.

Place, publisher, year, edition, pages
2001. Vol. 120, 175-178 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-25773DOI: 10.1159/000054784Local ID: 10207OAI: oai:DiVA.org:liu-25773DiVA: diva2:246321
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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Axelson, OlavLandtblom, Anne-MarieFlodin, Ulf

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Faculty of Health SciencesOccupational and Environmental MedicineOccupational and Environmental Medicine CentreNeurologyDepartment of Neurology
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