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Photopheresis at onset of type 1 diabetes: A randomised, double blind, placebo controlled trial
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
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2001 (English)In: Archives of Disease in Childhood, ISSN 0003-9888, Vol. 85, no 2, 149-154 p.Article in journal (Refereed) Published
Abstract [en]

Background - In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of immunomodulation. Aim - To evaluate its effect in type 1 diabetes we performed a double blind, controlled study using placebo tablets and sham pheresis in the control group. Methods - A total of 49 children, aged 10-18 years of age at diagnosis of type 1 diabetes were included, 40 fulfilled the study and were followed for three years (19 received active treatment with photopheresis and 21 placebo treatment). Results - The actively treated children secreted significantly more C peptide in urine during follow up than control children. C peptide values in serum showed corresponding differences between the two groups. The insulin dose/kg body weight needed to achieve satisfactory HbA1c values was always lower in the photopheresis group, there was no difference between the groups regarding HbAlc values during follow up. The treatment was well accepted except for nausea (n = 3) and urticaria (n = 1) in the actively treated group. There were no differences regarding weight or height, or episodes of infection between the two groups during follow up. Conclusion - Photopheresis does have an effect in addition to its possible placebo effect, shown as a weak but significant effect on the disease process at the onset of type 1 diabetes, an effect still noted after three years of follow up.

Place, publisher, year, edition, pages
2001. Vol. 85, no 2, 149-154 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-25804DOI: 10.1136/adc.85.2.149Local ID: 10241OAI: oai:DiVA.org:liu-25804DiVA: diva2:246352
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Ludvigsson, JohnnySamuelsson, UlfErnerudh, JanStenhammar, LarsBerlin, Gösta

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Archives of Disease in Childhood
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