Nerve conduction defects are retarded by tight metabolic control in type I diabetes
2001 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 24, no 2, 240-246 p.Article in journal (Refereed) Published
This follow-up study examines whether the development of nerve dysfunction is retarded by tight metabolic control in patients with type I diabetes mellitus. Seventy-one patients and 115 age-matched healthy control subjects underwent studies of nerve conduction in peroneal and sural nerves. The presence of diabetes was associated with a reduction in peroneal motor nerve conduction velocity (MCV) by 5.9 m/s, sural sensory nerve conduction velocity (SCV) by 3.4 m/s, and sural sensory nerve action potential (SNAP) amplitude by 22%. Dysfunction in peroneal MCV, sural SCV, and sural SNAP were related to long-term poor metabolic control. Eleven of 12 patients with HbA1c <6.5% had normal nerve conduction or abnormality in only one nerve as compared to 2 of 15 patients with HbA1c >8.0%. It is concluded that tight long-term metabolic control (HbA1c <6.5%) can retard nerve dysfunction in patients with type I diabetes mellitus and a mean disease duration of 12 years.
Place, publisher, year, edition, pages
2001. Vol. 24, no 2, 240-246 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-25930DOI: 10.1002/1097-4598(200102)24:2<240::AID-MUS90>3.0.CO;2-2Local ID: 10374OAI: oai:DiVA.org:liu-25930DiVA: diva2:246478