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Hypersecretion of ovarian androgens may be gonadotrophin dependent many years after menopause
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
2000 (English)In: Maturitas, ISSN 0378-5122, Vol. 34, no 1, 43-46 p.Article in journal (Refereed) Published
Abstract [en]

Background: In fertile women both adrenals and ovaries contribute to androgen production, whereas after the menopause the ovarian contribution normally decreases. Objective: The objective of this case study was to assess whether ovarian androgen secretion was responsive to decreased gonadotrophin stimulation and whether gonadotrophins were sensitive to negative feedback from sex steroids many years after the menopause. Methods: In this uncontrolled case study a 72 years old slightly overweight woman with noninsulin-dependent diabetes mellitus presented with hirsuitism and elevated serum testosterone concentrations. The woman was reluctant to have an oophorectomy, and received an oral estradiol/progestagene preparation. Serum testosterone and gonadotrophin concentrations were measured before and after steroid hormone therapy. Results: Serum gonadotrophin concentrations decreased and testosterone levels returned to normal during therapy. When the hormone therapy was stopped for 1 month the high testosterone concentrations returned, but were again normalized when the hormone therapy was reinitiated. Conclusion: The ovaries of this woman were apparently still responsive to pituitary stimulation and her hypothalamic-pituitary-ovarian feed-back system still seemed to be working after 70 years of age.

Place, publisher, year, edition, pages
2000. Vol. 34, no 1, 43-46 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-25932DOI: 10.1016/S0378-5122(99)00092-4Local ID: 10377OAI: oai:DiVA.org:liu-25932DiVA: diva2:246480
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-14

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Gunnarsson, CeciliaHammar, Mats

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Faculty of Health SciencesObstetrics and gynecologyDepartment of Surgery in Östergötland
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