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Allopurinol in addition to 5-aminosalicylic acid based drugs for the maintenance treatment of ulcerative colitis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, GE: gastromed.
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2000 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, Vol. 14, no 9, 1159-1162 p.Article in journal (Refereed) Published
Abstract [en]

Background: To investigate the value of combined treatment with allopurinol and 5-aminosalicylic (5-ASA) based drugs as maintenance treatment for ulcerative colitis (UC). Methods: 199 patients with UC in remission but with active disease during the preceding 3 years were included. Allopurinol 100 mg twice daily or placebo was added to the 5-ASA based maintenance treatment. Clinical and endoscopic follow up was performed after 1, 6 and 12 months. Results: Intention-to-treat analysis after 6 and 12 months showed similar results in both groups. A log-rank test showed that 77% in the allopurinol compared to 59% in the placebo group were still in remission after 6 months (P = 0.0083) and 62% and 53% after 12 months, respectively (P = 0.0936). This was mainly due to a higher than expected number of relapses during the first 3 months in the placebo group. After the first 3 months, the rate of relapse in each group was similar. Conclusions: It appears possible that allopurinol in combination with 5-ASA is better than 5-ASA alone for a 6-month, but not a 12-month period. This has to be verified in further dose-ranging studies.

Place, publisher, year, edition, pages
2000. Vol. 14, no 9, 1159-1162 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-25983DOI: 10.1046/j.1365-2036.2000.00821.xLocal ID: 10434OAI: oai:DiVA.org:liu-25983DiVA: diva2:246531
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-14

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Ström, Magnus

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