Effects of HIV co-infection and chemotherapy on the urinary levels of nitric oxide metabolites in patients with pulmonary tuberculosis
1999 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 31, no 2, 123-126 p.Article in journal (Refereed) Published
The presence of nitric oxide (NO) and its role as a factor in host defence against intracellular pathogens in human macrophages is controversial. We measured the metabolites of NO (nitrite (NO 2 -) and nitrate (NO 3 -)) in urine from Ethiopian patients suffering from tuberculosis. The urinary level of NO 2 -/NO 3 - in a group of healthy Ethiopians was 1020 ± 471 μM (n = 22). Untreated HIV negative patients with active pulmonary tuberculosis (1574 ± 588 μM, p < 0.01, n = 12) and household contacts to tuberculosis patients (1949 ± 812 μM, p = 0.006; n = 7) had significantly higher levels of urinary NO 2 -/NO 3 -, than the control group. Untreated HIV positive patients with pulmonary tuberculosis did not have increased levels of urinary NO 2 -/NO 3 -, (1101 ± 614 μM, n = 6). Some of the HIV negative untreated patients with pulmonary tuberculosis (1710 ± 519 μM, n = 6) were followed up after treatment and showed a reduction in the levels of urinary NO 2 -/NO 3 - 1 week after treatment (945 ± 599 μM, p < 0.05). We conclude that HIV negative patients with active pulmonary tuberculosis have increased urinary levels of nitric oxide metabolites with a reduction following specific anti-tuberculous chemotherapy.
Place, publisher, year, edition, pages
1999. Vol. 31, no 2, 123-126 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26096DOI: 10.1080/003655499750006137Local ID: 10555OAI: oai:DiVA.org:liu-26096DiVA: diva2:246644