High dose prednisolone treatment of leprosy patients undergoing reactions is associated with a rapid decrease in urinary nitric oxide metabolites and clinical improvement
2000 (English)In: Leprosy Review, ISSN 0305-7518, Vol. 71, no 3, 355-362 p.Article in journal (Refereed) Published
Evidence is accumulating that nitric oxide (NO) produced by macrophages has a role in the pathogenesis of reactions in leprosy. We followed the urinary levels of the metabolites of NO [nitrite (NO 2 -) and nitrate (NO 3 -)] and the clinical response to prednisolone treatment in leprosy patients (n = 9) admitted to ALERT leprosy hospital Addis Ababa, Ethiopia, because of reversal reaction (RR) or erythema nodosum leprosum (ENL). In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 ± 454 μM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 ± 414 μM, P < 0.05), and remained stable 4 (895 ± 385 μM, P < 0.02) and 6 weeks following treatment initiation (1048 ± 452 μM, P < 0.02). This decrease was also present when the reactional patients were subdivided according to the type of reaction (ENL, RR) and coincided with a clinical improvement. In patients showing a poor clinical response to steroids, no or minor effects on the urinary NO metabolite levels were observed. We conclude that there is a correlation between the decrease in urinary NO metabolites and a favourable clinical response after high dose prednisolone treatment of reactional leprosy patients.
Place, publisher, year, edition, pages
2000. Vol. 71, no 3, 355-362 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26098PubMedID: 11105495Local ID: 10557OAI: oai:DiVA.org:liu-26098DiVA: diva2:246646