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Improved asthma control with budesonide/formeterol in a single inhaler, compared with budesonide alone
Linköping University, Faculty of Health Sciences. Linköping University, Department of health and environment. Östergötlands Läns Landsting, Centre for Medicine, Allergy Centre UHL.
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2001 (English)In: European Respiratory Journal, ISSN 0903-1936, Vol. 18, no 2, 262-268 p.Article in journal (Refereed) Published
Abstract [en]

Budesonide/formoterol in a single inhaler was compared with budesonide alone, and with concurrent administration of budesonide and formoterol from separate inhalers, in patients with asthma, not controlled with inhaled glucocorticosteroids alone. In this 12-week, double-blind, randomized, double-dummy study, 362 adult asthmatics (forced expiratory volume in one second 73.8% of predicted, inhaled glucocorticosteroid dose 960 ╡g╖day-1) received single inhaler budesonide/formoterol (Symbicort « Turbuhaler «) 160/4.5 ╡g, two inhalations b.i.d., or corresponding treatment with budesonide, or budesonide plus formoterol via separate inhalers. There was a greater increase in morning peak expiratory flow (PEF) with single-inhaler (35.7 L╖min-1) and separate-inhaler (32.0 L╖min-1) budesonide and formoterol, compared with budesonide alone (0.2 L╖min-1, p<0.001, both comparisons), the effect was apparent after 1 day (p<0.001 versus budesonide, both comparisons). Similarly, evening PEF, use of rescue medication, total asthma symptom scores and percentage of symptom-free days improved more with both single inhaler and separate inhaler therapy than with budesonide alone, as did asthma control days (~15% more, p<0.001 versus budesonide, both comparisons, with a marked increase in the first week). All treatments were well tolerated and the adverse event profile was similar in all three treatment groups. It is concluded that single inhaler therapy with budesonide and formoterol is a clinically effective and well-tolerated treatment for patients with asthma that is not fully controlled by inhaled glucocorticosteroids alone.

Place, publisher, year, edition, pages
2001. Vol. 18, no 2, 262-268 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-26156DOI: 10.1183/09031936.01.00065801Local ID: 10615OAI: diva2:246704
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Zetterström, Olle
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Faculty of Health SciencesDepartment of health and environmentAllergy Centre UHL
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