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Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)
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2002 (English)In: Journal of Hepatology, ISSN 0168-8278, Vol. 36, no 5, 586-589 p.Article in journal (Refereed) Published
Abstract [en]

Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found.

Place, publisher, year, edition, pages
2002. Vol. 36, no 5, 586-589 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-26354DOI: 10.1016/S0168-8278(02)00036-3Local ID: 10888OAI: diva2:246902
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Almer, Sven
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Faculty of Health SciencesGastroenterology and HepatologyEMK-magtarm
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