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High hepatocyte growth factor levels in faeces during acute infectious gastroenteritis
Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Linköping University, Faculty of Health Sciences.
Department of Clinical Physiology, County Hospital, Kalmar.
Department of Clinical Chemistry, County Hospital, Kalmar.
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2003 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 35, no 11-12, 858-862 p.Article in journal (Refereed) Published
Abstract [en]

Hepatocyte growth factor (HGF) is a potent mitogen of mature epithelial cells which is produced after organ injuries and acts as a trigger for regeneration in the impaired organ. The aim of the present study was to investigate local production of HGF during infectious gastroenteritis. We measured the concentration of HGF in serum and faeces in 49 patients with acute infectious gastroenteritis (bacterium=30, virus=10, amoebae=1, and probable infection=8) at the time of referral to hospital and at convalescence (n=31). The values were compared with normal healthy vaccination volunteers (n=11) as well as patients with acute non-infectious diarrhoea (n=10). The presence of HGF in faeces was confirmed by ELISA and Western immunoblot. HGF concentrations in faeces was significantly higher in the patients with infectious gastroenteritis compared to the control groups (p<0.0001). Using a cut-off concentration of 20 ng/g, the overall sensitivity of faeces HGF to distinguish infectious gastroenteritis (bacterial, viral, probable infection) was 98% with a specificity of 100%. At convalescence all patients had normal values. There was no significant correlation between HGF concentrations in faeces and serum. Determination of faeces HGF may identify cases of transmittable diarrhoea requiring isolation at an early stage.

Place, publisher, year, edition, pages
2003. Vol. 35, no 11-12, 858-862 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-26360DOI: 10.1080/00365540310016484Local ID: 10894OAI: diva2:246909
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-09-14Bibliographically approved

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Nayeri, FaribaAlmer, SvenÅkerlind, BrittForsberg, Pia
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Infectious DiseasesFaculty of Health SciencesGastroenterology and HepatologyClinical Microbiology
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