High body mass index, asthma and allergy in Swedish schoolchildren participating in the International Study of Asthma and Allergies in Childhood: phase II
2003 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 92, no 10, 1144-1148 p.Article in journal (Refereed) Published
Aim: To assess the relationship between high body mass index (BMI) and asthma and atopic manifestations in 12-y-old children.
Methods: The relationship between high BMI and asthma symptoms was studied in 457 sixth-grade children, with (n= 161) and without (n= 296) current wheeze. High BMI was defined as ±75th percentile of gender-specific BMI reference values for Swedish children at 12 y of age; overweight as a subgroup of high BMI was defined as ±95th percentile. Children with a BMI >75th percentile served as controls. Questionnaires were used to assess asthmatic and allergic symptoms, and bronchial hyperresponsiveness was assessed by hypertonic saline provocation tests.
Results: Current wheeze was associated with high BMI after adjustment for confounding factors (adjusted OR 1.7, 95% CI 1.0–2.5) and overweight had an even more pronounced effect (adjusted OR 1.9, 95% CI 1.0–3.6). In addition, asthma severity was associated with high BMI, as evaluated by the number of wheezing episodes during the previous 12 mo among the wheezing children (adjusted OR 2.0, 95% CI 1.0–4.0). There was also an association between high BMI and the presence of eczema in wheezing children (adjusted OR 2.2, 95% CI 1.0–4.6). However, high BMI was not significantly associated with hay fever, positive skin prick tests or bronchial hyperresponsiveness.
Conclusion: The study confirms and extends a previously observed relationship between BMI and the presence of wheezing and asthma.
Place, publisher, year, edition, pages
2003. Vol. 92, no 10, 1144-1148 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26373DOI: 10.1080/08035250310005666Local ID: 10907OAI: oai:DiVA.org:liu-26373DiVA: diva2:246922