Differences in sensory thresholds in the skin of women with fibromyalgia syndrome: A comparison between ketamine responders and ketamine non-responders
2003 (English)In: Journal of Musculoskeletal Pain, ISSN 1058-2452, E-ISSN 1540-7012, Vol. 11, no 2, 3-9 p.Article in journal (Refereed) Published
Objectives: To compare detection and pain thresholds in the skin of female fibromyalgia patients who were either ketamine responders or ketamine nonresponders.
Methods: Detection thresholds to innocuous warmth, of cold, heat or cold pain, and touch and dynamic touch sensation were determined in the skin. Pressure pain thresholds, local and widespread pain intensity, and pain duration were also registered.
Results: Ketamine nonresponse was associated with more pronounced hypersensitivity for thermal pain [especially cold pain] than ketamine response.
Conclusions: Blockade of N-metyl-D-aspartic acid receptors by ketamine and the recording of pain thresholds in the skin, especially for cold pain, might reveal different mechanisms of allodynia.
Place, publisher, year, edition, pages
2003. Vol. 11, no 2, 3-9 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26380DOI: 10.1300/J094v11n02_02Local ID: 10914OAI: oai:DiVA.org:liu-26380DiVA: diva2:246929