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Differences in sensory thresholds in the skin of women with fibromyalgia syndrome: A comparison between ketamine responders and ketamine non-responders
Linköping University, Department of Neuroscience and Locomotion, Rehabilitation Medicine. Östergötlands Läns Landsting, Pain and Occupational Centre, Pain and Rehabilitation Centre. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Neuroscience and Locomotion, Rehabilitation Medicine. Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
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2003 (English)In: Journal of Musculoskeletal Pain, ISSN 1058-2452, E-ISSN 1540-7012, Vol. 11, no 2, 3-9 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To compare detection and pain thresholds in the skin of female fibromyalgia patients who were either ketamine responders or ketamine nonresponders.

Methods: Detection thresholds to innocuous warmth, of cold, heat or cold pain, and touch and dynamic touch sensation were determined in the skin. Pressure pain thresholds, local and widespread pain intensity, and pain duration were also registered.

Results: Ketamine nonresponse was associated with more pronounced hypersensitivity for thermal pain [especially cold pain] than ketamine response.

Conclusions: Blockade of N-metyl-D-aspartic acid receptors by ketamine and the recording of pain thresholds in the skin, especially for cold pain, might reveal different mechanisms of allodynia.

Place, publisher, year, edition, pages
2003. Vol. 11, no 2, 3-9 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-26380DOI: 10.1300/J094v11n02_02Local ID: 10914OAI: oai:DiVA.org:liu-26380DiVA: diva2:246929
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved

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Aspegren Kendall, SallyHenriksson, Karl-GöstaHurtig, IngridRaak, RagnhildBengtsson, AnnWahren, Lis KarinGerdle, Björn

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Aspegren Kendall, SallyHenriksson, Karl-GöstaHurtig, IngridRaak, RagnhildBengtsson, AnnWahren, Lis KarinGerdle, Björn
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Rehabilitation MedicinePain and Rehabilitation CentreFaculty of Health SciencesPain and Rehabilitation CentrePharmacologyRheumatology
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Journal of Musculoskeletal Pain
Medical and Health Sciences

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