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Increased IFN-? response to transplantation antigens measured by cytokine MLC: Indications for a bi-phasic response pattern
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.ORCID iD: 0000-0002-3993-9985
2003 (English)In: Transplant Immunology, ISSN 0966-3274, E-ISSN 1878-5492, Vol. 11, no 1, 101-105 p.Article in journal (Refereed) Published
Abstract [en]

The immunological reactivity to major histocompatibility transplantation antigens (MHC) is important in clinical manifestations such as graft rejection and graft-vs.-host disease. To evaluate the allogeneic cytokine response pattern we used a newly developed cytokine mixed leukocyte culture (MLC) technique. Blood mononuclear cells from healthy women (n=6) were exposed to cells from another person and to pooled cells from 28 blood donors (MHC-pool). The secretion kinetics of IL-4 and IFN-? from the responder cells was analysed by ELISPOT. We found a higher IFN-? response to the MHC-pool compared with the IL-4 secretion. Both the total secretion of IFN-? for 7 days and the median value of IFN-? in each individual was increased compared with IL-4. The IFN-? response showed a bi-phasic pattern with the major peak on day 6-7. Our results indicate that allo-responses are mainly Thl-like responses, displaying a bi-phasic pattern. This knowledge may be useful, and the methods suitable, in the studies of allo-responses in transplantation and pregnancy.

Place, publisher, year, edition, pages
2003. Vol. 11, no 1, 101-105 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-26418DOI: 10.1016/S0966-3274(02)00146-6Local ID: 10960OAI: oai:DiVA.org:liu-26418DiVA: diva2:246967
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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Ekerfelt, Christina

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