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Phenotypes indicating cytolytic properties of Borrelia-specific interferon-? secreting cells in chronic Lyme neuroborreliosis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.ORCID iD: 0000-0002-3993-9985
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology.
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2003 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, Vol. 145, no 1-2, 115-126 p.Article in journal (Refereed) Published
Abstract [en]

The immuno-pathogenetic mechanisms underlying chronic Lyme neuroborreliosis are mainly unknown. Human Borrelia burgdorferi (Bb) infection is associated with Bb-specific secretion of interferon-? (IFN-?), which may be important for the elimination of Bb, but this may also cause tissue injury. In order to increase the understanding of the pathogenic mechanisms in chronic neuroborreliosis, we investigated which cell types that secrete IFN-?. Blood mononuclear cells from 13 patients with neuroborreliosis and/or acrodermatitis chronicum atrophicans were stimulated with Bb antigen and the phenotypes of the induced IFN-?-secreting cells were analyzed with three different approaches. Cells expressing CD8 or TCR?d, which both have cytolytic properties, were the main phenotypes of IFN-?-secreting cells, indicating that tissue injury in chronic neuroborreliosis may be mediated by cytotoxic cells.

Place, publisher, year, edition, pages
2003. Vol. 145, no 1-2, 115-126 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-26423DOI: 10.1016/j.jneuroim.2003.08.037Local ID: 10965OAI: oai:DiVA.org:liu-26423DiVA: diva2:246972
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2013-08-29

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Ekerfelt, ChristinaJarefors, SaraForsberg, PiaErnerudh, Jan

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Ekerfelt, ChristinaJarefors, SaraForsberg, PiaErnerudh, Jan
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Faculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion MedicineInfectious DiseasesDepartment of Infectious Diseases in Östergötland
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Journal of Neuroimmunology
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