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Hypointensity in T2-weighted images of the basal ganglia in solvent-exposed patients with multiple sclerosis: Clinical, MRI and CSF characteristics
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine. Östergötlands Läns Landsting, Pain and Occupational Centre, Occupational and Environmental Medicine Centre.
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2003 (English)In: Neurological Sciences, ISSN 1590-1874, E-ISSN 1590-3478, Vol. 24, no 1Article in journal (Refereed) Published
Abstract [en]

Several studies have indicated an association between MS and organic solvent exposure. Our objective was to analyse differences regarding cerebrospinal fluid (CSF) properties, magnetic resonance imaging (MRI) features and cerebral metabolites, measured by proton spectroscopy (1H-MRS), in 20 patients with spontaneous multiple sclerosis (MS) and in 20 patients with MS after solvent exposure, 15 healthy subjects served as controls. CSF examinations were retrospectively reviewed from the medical files. There were no significant differences in the CSF regarding pleocytosis, spinal-serum albumin ratio or mean extended IgG index. However, T2-weighted images of the solvent-exposed MS patients showed more hypointense areas in the basal ganglia. Hypointensity on T2-weighted images of the basal ganglia in the solvent-exposed MS patients may correspond to neurodegeneration and could be an early event in MS.

Place, publisher, year, edition, pages
2003. Vol. 24, no 1
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-26444DOI: 10.1007/s100720300014Local ID: 10987OAI: oai:DiVA.org:liu-26444DiVA: diva2:246993
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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Landtblom, Anne-MarieFlodin, UlfSöderfeldt, Birgitta

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Faculty of Health SciencesDepartment of Neuroscience and LocomotionDepartment of NeurologyOccupational and Environmental MedicineOccupational and Environmental Medicine Centre
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Neurological Sciences
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