Hypointensity in T2-weighted images of the basal ganglia in solvent-exposed patients with multiple sclerosis: Clinical, MRI and CSF characteristics
2003 (English)In: Neurological Sciences, ISSN 1590-1874, Vol. 24, no 1Article in journal (Refereed) Published
Several studies have indicated an association between MS and organic solvent exposure. Our objective was to analyse differences regarding cerebrospinal fluid (CSF) properties, magnetic resonance imaging (MRI) features and cerebral metabolites, measured by proton spectroscopy (1H-MRS), in 20 patients with spontaneous multiple sclerosis (MS) and in 20 patients with MS after solvent exposure, 15 healthy subjects served as controls. CSF examinations were retrospectively reviewed from the medical files. There were no significant differences in the CSF regarding pleocytosis, spinal-serum albumin ratio or mean extended IgG index. However, T2-weighted images of the solvent-exposed MS patients showed more hypointense areas in the basal ganglia. Hypointensity on T2-weighted images of the basal ganglia in the solvent-exposed MS patients may correspond to neurodegeneration and could be an early event in MS.
Place, publisher, year, edition, pages
2003. Vol. 24, no 1
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26444DOI: 10.1007/s100720300014Local ID: 10987OAI: oai:DiVA.org:liu-26444DiVA: diva2:246993