Exhaled breath condensate and serum levels of hepatocyte growth factor in pneumonia
2002 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 96, no 2, 115-119 p.Article in journal (Refereed) Published
Hepatocyte growth factor (HGF) is a protein produced by mesenchymal cells in many organs, which can stimulate epithelial growth. An enhanced production and concentration of HGF is observed after injuries. The lung is one of the major sources of HGF. By cooling exhaled air, a condensate is formed containing molecules from bronchi and alveoli. In order to investigate HGF concentration and time course in pneumonia, paired serum and exhaled breath condensate was collected from 10 patients with pneumonia, 10 patients with non-respiratory infections and 11 healthy controls. The concentration of HGF was measured by an immunoassay kit. In the acute phase HGF-levels in breath condensate and serum were significantly higher in the patients with pneumonia compared to the control groups. Similar concentrations in breath condensate were seen in healthy controls and in patients with non-respiratory infections. In the patients with pneumonia a decrease in serum HGF was seen already after 4–7 days while HGF values in breath condensate remained elevated even after 4–6 weeks. These results might imply local production of HGF in the lungs and a long repair and healing process after pneumonia.
Place, publisher, year, edition, pages
2002. Vol. 96, no 2, 115-119 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26447DOI: 10.1053/rmed.2001.1225Local ID: 10991OAI: oai:DiVA.org:liu-26447DiVA: diva2:246996