Helicobacter pylori sabA adhesin in persistent infection and chronic inflammation
2002 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 297, no 5581, 573-578 p.Article in journal (Refereed) Published
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show thatH. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid–binding adhesin (SabA) was isolated with the “retagging” method, and the underlyingsabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.
Place, publisher, year, edition, pages
2002. Vol. 297, no 5581, 573-578 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26539DOI: 10.1126/science.1069076Local ID: 11100OAI: oai:DiVA.org:liu-26539DiVA: diva2:247088