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Translocation of transcription regulators into the nucleus during granulocyte commitment of HL-60 cells
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
Department of Developmental Biology, Institute of Biochemistry, Lithuania, and Department of Biological Chemistry, School of Medicine, University of California at Davis, U.S.A..
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2003 (English)In: Biochemistry and Cell Biology, ISSN 0829-8211, E-ISSN 1208-6002, Vol. 81, no 4, 285-295 p.Article in journal (Refereed) Published
Abstract [en]

Expression of transcription factors required for lineage commitment of differentiating cells (C/EBPβ and c-Myb) and for survival of differentiated cells (STATs and NFκB) was examined in the HL-60 cell line. Differentiation was induced by treating the cells with retinoic acid. c-Myb expression in the nucleus restored at the precommitment stage (18 h) what concurred with the highest nuclear level of C/EBPβ, which suggests a combinatorial interaction of these transcription factors in the granulocytic signalling pathway. Expression of STAT5a and STAT5b varied during differentiation, whereas no significant changes were seen in STAT3 levels. Increased cytosolic level of NFκB p65 during precommitment and commitment stages of granulocytic differentiation coincided with augmentation of the STAT5a protein level, which could be evidence of their possible cooperation during granulocytic-lineage commitment of HL-60 cells. Our results suggest that the studied transcription factors cooperatively promote signalling in the differentiating promyelocytic HL-60 cell line in response to retinoic acid.

Place, publisher, year, edition, pages
2003. Vol. 81, no 4, 285-295 p.
Keyword [en]
C/EBP, Myb, STAT, NFκB, phosphorylation.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-26541DOI: 10.1139/o03-055Local ID: 11103OAI: oai:DiVA.org:liu-26541DiVA: diva2:247090
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved

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Navakauskiene, RutaMagnusson, Karl-Eric

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