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Pharmacodynamic effects of nitroimidazoles alone and in combination with clarithromycin on Helicobacter pylori
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, EMK-magtarm.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine.
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2002 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, Vol. 46, no 7, 2244-2248 p.Article in journal (Refereed) Published
Abstract [en]

Pharmacodynamic studies of Helicobacter pylori exposed to metronidazole and tinidazole alone and in combination with clarithromycin were performed by bioluminescence assay of intracellular ATP. The pharmacodynamic parameter control-related effective regrowth time (CERT) was used. CERT is defined as the time required for the resumption of logarithmic growth and a return of the level of growth to the preexposure inoculum in the test culture minus the corresponding time in the control culture. CERT measures the combined effects of the initial level of killing and postantibiotic effect. The incubation times and drug concentrations were chosen according to their half-lives and their clinically achievable concentrations. The study shows that the parameter CERT is useful for the testing of antibiotic combinations. The CERTs induced by clarithromycin, metronidazole, and tinidazole alone and in the combinations tested were concentration dependent, with no maximum response, indicating that the use of high doses may be preferable. The combinations with the highest concentrations induced synergistic effects and prevented regrowth. The use of tinidazole in combination with clarithromycin proved to give the longest CERTs, indicating that this is the most effective combination.

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2002. Vol. 46, no 7, 2244-2248 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-26548DOI: 10.1128/AAC.46.7.2244-2248.2002Local ID: 11110OAI: oai:DiVA.org:liu-26548DiVA: diva2:247097
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Ström, MagnusNilsson, MaudNilsson, Lennart

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Ström, MagnusNilsson, MaudNilsson, Lennart
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Faculty of Health SciencesDepartment of Molecular and Clinical MedicineGastroenterology and HepatologyEMK-magtarm
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