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Analysis of PorA variable region 3 in meningococci: implications for vaccine policy?
Scottish Meningococcus and Pneumococcus Reference Laboratory, North Glasgow University Hospitals NHS Trust, Stobhill Hospital, Scotland, UK and Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
Scottish Meningococcus and Pneumococcus Reference Laboratory, North Glasgow University Hospitals NHS Trust, Stobhill Hospital, Scotland, UK.
National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden.
National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden.
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2003 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 21, no 19-20, 2468-2473 p.Article in journal (Refereed) Published
Abstract [en]

Outer membrane protein (OMP) vaccines are being developed against Neisseria meningitidis serogroup B which may provide protection against common circulating serotypes and serosubtypes in some countries. However, limited data is available in Europe from genosubtyping meningococci. We therefore undertook a retrospective analysis of the three main variable regions, VR1, VR2 as well as VR3, of the porA gene from N. meningitidis isolated from different countries, mainly from Scotland and Sweden. Analysis of this gene showed that, amongst 226 strains studied, there were a total of 78 different strains. No new VR1 or VR2 alleles were found but five new VR3 alleles are described. Our data indicates the importance of analysing the VR3 region of PorA in addition to VR1 and VR2 and also highlights, in general terms, the need for genosubtyping meningococci. Such analyses have major implications for the design of new meningococcal vaccines.

Place, publisher, year, edition, pages
2003. Vol. 21, no 19-20, 2468-2473 p.
Keyword [en]
Neisseria meningitidis, Meningococci, porA, Sequence typing, Vaccine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-26554DOI: 10.1016/S0264-410X(03)00033-1Local ID: 11116OAI: oai:DiVA.org:liu-26554DiVA: diva2:247103
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved

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Unemo, MagnusOlcén, Per

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