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Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Barn.
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2003 (English)In: Diabetes, ISSN 0012-1797, Vol. 52, no 9, 2287-2295 p.Article in journal (Refereed) Published
Abstract [en]

Involvement of gut immune system has been implicated in the pathogenesis of type 1 diabetes. However, few studies have been performed on the gut mucosa from patients with type 1 diabetes. Thus, we characterized the stage of immune activation in jejunal biopsy samples from 31 children with type 1 diabetes by immunohistochemistry, in situ hybridization, and RT-PCR. We found enhanced expressions of HLA-DR, HLA-DP, and intercellular adhesion molecule-1 by immunohistochemistry even on structurally normal intestine of patients with type 1 diabetes and no signs of celiac disease. In addition, the densities of IL-1a- and IL-4-positive cells detected by immunohistochemistry and IL-4 mRNA-expressing cells evaluated by in situ hybridization were increased in the lamina propria in patients with type 1 diabetes and normal mucosa. Instead, the densities of IL-2, ?-interferon (IFN-?), and tumor necrosis factor a-positive cells, the density of IFN-? mRNA positive cells, and the amounts of IFN-? mRNA detected by RT-PCR correlated with the degree of celiac disease in patients with type 1 diabetes. Our study supports the hypothesis that a link exists between the gut immune system and type 1 diabetes.

Place, publisher, year, edition, pages
2003. Vol. 52, no 9, 2287-2295 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-26602DOI: 10.2337/diabetes.52.9.2287Local ID: 11167OAI: diva2:247151
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Vaarala, Outi
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