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Components with potential immunosuppressive activity in lipopolysaccharide of laboratory Pseudomonas aeruginosa strains
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
2003 (English)In: Immunology Letters, ISSN 0165-2478, Vol. 85, no 1, 29-33 p.Article in journal (Refereed) Published
Abstract [en]

The ability of culture filtrate (CF) of two laboratory Pseudomonas aeruginosa strains to inhibit delayed type hypersensitivity (DTH) to non-bacterial antigen in CBA mice has been studied. It was shown that intraperitoneal injection of native CF of the strains did not affect the level of DTH. However, redox treated CF expressed the immunosuppressive activity. Gel filtration of redox activated CF through Sephadex G-200 showed that CF contains three immunosuppressive components differing by their molecular weight and specificity. All components contained lipid group and O-polysaccharide chains that indicated their lipopolysaccharide (LPS) nature. These experiments show that laboratory P. aeruginosa strains have three LPS components but not all of them display the immunosuppressive activity.

Place, publisher, year, edition, pages
2003. Vol. 85, no 1, 29-33 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-26608DOI: 10.1016/S0165-2478(02)00205-5Local ID: 11173OAI: diva2:247157
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Vikström, Olena
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