Disposition of venlafaxine enantiomers in rats with hepatic encephalopathy after chronic drug treatment
2002 (English)In: Chirality, ISSN 0899-0042, Vol. 14, no 4, 347-350 p.Article in journal (Refereed) Published
Portacaval shunted (PCS) rats, a model of hepatic encephalopathy, and control animals were administered racemic venlafaxine for 14 days (10 mg/kg). The levels of the S- and R-enantiomers and the S/R-enantiomer ratios of venlafaxine and its metabolites were assessed by an enantiomer-selective chromatographic assay in serum, brain parenchyma, and brain dialysate of both groups. Higher levels of the S- and R-enantiomers of venlafaxine were found in serum and brain of PCS vs. normal rats (median values of S- and R-venlafaxine in serum: 290 and 201 nM in PCS, 97 and 66 nM in normal rats, median values of S- and R-venlafaxine in cortex: 956 and 939 nM in PCS, 357 and 318 nM in normal rats). Interestingly, similar S/R-venlafaxine ratios were observed in PCS and normal rats both in serum (S/R = 1.4) and brain compartments (S/R = 1.0-1.1). These findings may have clinical relevance for the safety of venlafaxine in chronic hepatic encephalopathy. ⌐ 2002 Wiley-Liss, Inc.
Place, publisher, year, edition, pages
2002. Vol. 14, no 4, 347-350 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26735DOI: 10.1002/chir.10088Local ID: 11330OAI: oai:DiVA.org:liu-26735DiVA: diva2:247285