liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Is there a change in myocardial nonlinearity during the cardiac cycle?
Departments of Cardiology University of Leuven, Leuven, Belgium.
Department of Electrical Engineering, Medical Image Computing, University of Leuven, Leuven, Belgium.
Departments of Cardiology University of Leuven, Leuven, Belgium.
Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
Show others and affiliations
2001 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, Vol. 27, no 3, 389-398 p.Article in journal (Refereed) Published
Abstract [en]

The distortion of a sound wave during propagation results in progressive transfer of the energy from fundamental to higher harmonics, and is dependent on the nonlinearity of the medium. We studied if relative changes in acoustical nonlinearity occur in healthy myocardium during the cardiac cycle. Radiofrequency data were acquired from transthoracic echocardiography (2.5 and 3.5 MHz), parasternal long axis view, from five dogs and nine healthy volunteers. Integrated backscatter was calculated after filtering for fundamental (FIB) and second harmonic frequencies (SHIB), from a region in the posterior myocardial wall. The results suggest that there is little difference between the SHIB and FIB, although there were large variations between individuals. The maximal changes in nonlinearity, as estimated by SHIB/FIB ratio, mostly occurred during systole. SHIB presented similar cyclic variation with FIB (p = NS). Further studies are necessary to separate the role of myocardial nonlinearity, attenuation, propagating distance, or acoustical properties of the blood. The results are important in further tissue characterization studies employing second harmonic data.

Place, publisher, year, edition, pages
2001. Vol. 27, no 3, 389-398 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-26825DOI: 10.1016/S0301-5629(00)00336-7Local ID: 11439OAI: diva2:247375
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-12-10

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Brandt, Einar
By organisation
Department of Clinical Physiology
In the same journal
Ultrasound in Medicine and Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link