liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Is left ventricular postsystolic long-axis shortening a marker for severity of hypertensive heart disease?
Linköping University, Department of Medicine and Care, Clinical Physiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-2198-9690
Linköping University, Department of Medicine and Care, Clinical Physiology. Linköping University, Faculty of Health Sciences.
Institute of Cardiology of Kaunas Medical University, Kaunas, Lithuania.
2003 (English)In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 91, no 12, 1490-1493 p.Article in journal (Refereed) Published
Abstract [en]

No abstract available.

Place, publisher, year, edition, pages
2003. Vol. 91, no 12, 1490-1493 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-26833DOI: 10.1016/S0002-9149(03)00407-7Local ID: 11448OAI: oai:DiVA.org:liu-26833DiVA: diva2:247383
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2013-12-17Bibliographically approved
In thesis
1. Annular dynamics of the human heart: novel echocardiographic approaches to assess ventricular function
Open this publication in new window or tab >>Annular dynamics of the human heart: novel echocardiographic approaches to assess ventricular function
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The complex myocardial fiber architecture of the left ventricle (LV) enables long-axis motion (annular excursion), short-axis motion and also a small torsional deformation throughout the cardiac cycle. The contribution of the long-axis motion has proven to be important in generating ventricular filling and emptying, and the analysis of annular excursion has become a well established diagnostic tool for the assessment of ventricular function. Cardiac motion can be accurately described with modem non-invasive imaging teclmiques, and this is important ground for deeper understanding and more reliable diagnosis of cardiovascular disease. The focus of this thesis was to provide new insights into cardiac pump function using variables originating from the annular excursion and dynamic changes in shape, applying both established and novel echocardiographic imaging approaches.

The traditional method of evaluating systolic ventricular fimction according to the total annular excursion overestimates the excursion amplitude in relation to true systolic fimction. A novel method presented here, measurement of the systolic annular excursion, more accurately reflects the timing of true systole, and was applied both in patients with heart disease and in healthy subjects. To date, the form of asynchronous myocardial motion called postsystolic shortening (PSS) has mainly been observed in the setting of myocardial ischemia. The significance of PSS in hypertensive heart disease remains incompletely described. We found that a subgroup of hypertensive patients with PSS along the LV long-axis had signs of more severe cardiac involvement unrelated to the level of blood pressure. Endurance trained subjects showed a larger LV long-axis motion as compared to strength trained and untrained controls. Mitral annular (MA) excursion correlated strongly to LV stroke volume, end-diastolic volume and maximal oxygen consumption per body weight, but weakly to LV ejection fraction. These findings provide further evidence of the importance of annular excursion to normal cardiac performance. In order to assess the contribution of MA excursion and shape dynamics to total LV volume change in humans, a novel 4-dimensional transesophageal echocardiography teclmique was developed. The excursion of the annulus accounted for an important portion (19±3%) of the total LV filling and emptying in healthy human subjects. Furthermore, our findings elucidate an atrial influence on MA physiology in humans, as well as a sphincter-like action of the MA. These temporal changes may facilitate ventricular filling by annular expansion during early and mid diastole, and aid competent valve closure during the marked decrease in annular area during late diastole and early systole.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2004. 72 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 871
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-23445 (URN)2897 (Local ID)91-7373-847-6 (ISBN)2897 (Archive number)2897 (OAI)
Public defence
2004-12-03, Elsa Brändströmsalen, Universitetssjukhuset, Linköping, 09:00 (Swedish)
Opponent
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2013-12-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Carlhäll, CarljohanWranne, Bengt

Search in DiVA

By author/editor
Carlhäll, CarljohanWranne, Bengt
By organisation
Clinical PhysiologyFaculty of Health Sciences
In the same journal
American Journal of Cardiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 65 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf