A case of Kleine-Levin syndrome examined with SPECT and neuropsychological testing
2002 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, Vol. 105, no 4, 318-321 p.Article in journal (Refereed) Published
A case of Kleine-Levin syndrome with typical periodic hypersomnia and bulemia was diagnosed. On examination with single photo emission tomography (SPECT) (CERETEC«) during a relapse period and 2 weeks later there was marked cortical hypoperfusion of the frontal and temporal lobes, especially on the left side as well as in the right parietal lobe. Neuropsychological testing performed 1 week after a relapse showed a reduction in encoding to memory function of verbal learning indicating neocortical damage of the left fronto-temporal region. A follow-up 2 months later after the patient had spontaneously recovered showed only a slight left fronto-temporal disturbance. CT and MRI of the brain were normal although the MRI showed a large and asymmetric mamillary body. Neuropsychological testing 6 years after recovery showed pronounced reduction in short-time verbal and visual memory. Seven years after recovery SPECT demonstrated a normalized frontal perfusion but still a slight hypoperfusion in the left temporal lobe. Our results correlate to autopsy findings in two cases described previously.
Place, publisher, year, edition, pages
2002. Vol. 105, no 4, 318-321 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-26911DOI: 10.1034/j.1600-0404.2002.1c162.xLocal ID: 11535OAI: oai:DiVA.org:liu-26911DiVA: diva2:247461