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A case of Kleine-Levin syndrome examined with SPECT and neuropsychological testing
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
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2002 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 105, no 4, 318-321 p.Article in journal (Refereed) Published
Abstract [en]

A case of Kleine-Levin syndrome with typical periodic hypersomnia and bulemia was diagnosed. On examination with single photo emission tomography (SPECT) (CERETEC«) during a relapse period and 2 weeks later there was marked cortical hypoperfusion of the frontal and temporal lobes, especially on the left side as well as in the right parietal lobe. Neuropsychological testing performed 1 week after a relapse showed a reduction in encoding to memory function of verbal learning indicating neocortical damage of the left fronto-temporal region. A follow-up 2 months later after the patient had spontaneously recovered showed only a slight left fronto-temporal disturbance. CT and MRI of the brain were normal although the MRI showed a large and asymmetric mamillary body. Neuropsychological testing 6 years after recovery showed pronounced reduction in short-time verbal and visual memory. Seven years after recovery SPECT demonstrated a normalized frontal perfusion but still a slight hypoperfusion in the left temporal lobe. Our results correlate to autopsy findings in two cases described previously.

Place, publisher, year, edition, pages
2002. Vol. 105, no 4, 318-321 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-26911DOI: 10.1034/j.1600-0404.2002.1c162.xLocal ID: 11535OAI: oai:DiVA.org:liu-26911DiVA: diva2:247461
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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Landtblom, Anne-MarieSäfström, KågeGranerus, Göran

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Faculty of Health SciencesDepartment of Neuroscience and LocomotionDepartment of NeurologyRadiologyDepartment of Radiology UHLClinical PhysiologyDepartment of Clinical Physiology
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Acta Neurologica Scandinavica
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