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Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man
Department of Internal Medicine, Helsingborg Hospital, Helsingborg, Sweden.
Department of Endocrinology, Malmö University Hospital, Malmö, Sweden.
Linköping University, Department of Medicine and Care. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-9095-403X
2003 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 90, no 1-2, 138-143 p.Article in journal (Refereed) Published
Abstract [en]

This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH2O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were recorded with volumetric technique. Forearm blood flow increased during HI from 2.3 (0.3) ml (100 ml)–1 min–1 to 3.3 (0.5) ml (100 ml)–1 min–1 (P<0.05). The haemodynamic response to LBNP was similar during HI and HG compared with control LBNP. Transcapillary fluid absorption during LBNP increased during HG from 0.044 (0.007) ml (100 ml)–1 min–1 to 0.059 (0.009) ml (100 ml)–1 min–1 (P<0.01), whereas it was unchanged during HI. In conclusion, hyperglycaemia augments transcapillary fluid absorption from skeletal muscle and skin during LBNP whereas hyperinsulinaemia has no such effect. This indicates that in human hyperglycaemia contributes to plasma volume restitution during hypovolaemic circulatory stress.

Place, publisher, year, edition, pages
2003. Vol. 90, no 1-2, 138-143 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-27035DOI: 10.1007/s00421-003-0894-3Local ID: 11679OAI: oai:DiVA.org:liu-27035DiVA: diva2:247586
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved

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Länne, Toste

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