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Nurse-recorded and ambulatory blood pressure predicts treatment-induced reduction of left ventricular hypertrophy equally well in hypertension: Results from the Swedish irbesartan left ventricular hypertrophy investigation versus atenolol (SILVHIA) study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, EMK-endokrin.ORCID iD: 0000-0002-1680-1000
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine.
2002 (English)In: Journal of Hypertension, ISSN 0263-6352, Vol. 20, no 8, 1527-1533 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To compare the relationships of treatment-induced reductions of left ventricular hypertrophy to the changes in clinic and ambulatory blood pressure (BP). Design: Double-blind and randomized treatment with irbesartan or atenolol for 48 weeks. Patients: Patients with hypertension and left ventricular hypertrophy (n = 66) with a seated diastolic BP 90-115 mmHg (average of three measurements one minute apart by nurses). Main outcome measures: Registrations of echocardiographic left ventricular (LV) mass. Clinic and ambulatory BP. Results: In the total material, nurse-measured BP was reduced by 23 +/- 15/16 +/- 7.7 mmHg and 24-h ambulatory BP fell 20 +/- 15/14 +/- 8.5 mmHg by treatment. The correlation between the change in nurse-measured BP and LV mass index (LVMI) induced by treatment was r = 0.35, P = 0.004 for systolic BP and r = 0.26, P = 0.03 for diastolic BP. Corresponding values for 24-h ambulatory BP were r = 0.29, P = 0.02 and r = 0.35, P = 0.004, respectively, with similar correlations for day- and night-time ambulatory BP. The nurse-recorded BP was slightly higher than ambulatory BP (systolic clinic - systolic 24-h ambulatory BP = 5 mmHg). Using 130/80 mmHg as a cut-off value for normal 24-h ambulatory BP, eight subjects had normal diastolic or systolic ambulatory BP, or both. Interestingly, these patients also experienced LVMI regression following treatment (low/normal ABP, -13 +/- 21 g/m2, remaining patients, -18 +/- 22 g/m2, P > 0.5). Conclusions: In patients with hypertension and left ventricular hypertrophy, ambulatory BP is not superior to carefully standardized nurse-recorded seated BP in terms of associations with treatment-induced changes in LV mass.

Place, publisher, year, edition, pages
2002. Vol. 20, no 8, 1527-1533 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27064DOI: 10.1097/00004872-200208000-00015Local ID: 11711OAI: diva2:247615
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2013-09-10

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