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Statin therapy and reductions in low-density lipoprotein cholesterol: Initial clinical data on the potent new statin rosuvastatin
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, MKC-2, GE: endomed.
2001 (English)In: American Journal of Cardiology, ISSN 0002-9149, Vol. 87, no 5 SUPPL. 1Article in journal (Refereed) Published
Abstract [en]

The utility of statins with increased potency in reducing low-density lipoprotein cholesterol (LDL-C) is indicated by evidence that aggressive LDL-C lowering is associated with increased reduction in coronary artery disease risk, and the need for such agents is illustrated by the fact that many patients currently fail to achieve LDL-C target levels during treatment with available drugs. In dose-ranging studies of patients with hypercholesterolemia, the new synthetic statin rosuvastatin (formerly ZD4522) produced significant, dose-dependent reductions in LDL-C compared with placebo across a range of doses. Reductions ranged from 34% at 1 mg per day to 65% at 80 mg per day, with linear regression analysis indicating an additional 4.5% reduction in LDL-C with each doubling of the rosuvastatin dose. Rosuvastatin treatment was well tolerated. Phase 3 clinical trials of this agent are under way.

Place, publisher, year, edition, pages
2001. Vol. 87, no 5 SUPPL. 1
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27096Local ID: 11743OAI: diva2:247647
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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