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Effects of middle ear pressure changes on clinical symptoms in patients with MΘniΦre's disease - A clinical multicentre placebo-controlled study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Technical Audiology. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
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2000 (English)In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, no 543, 99-101 p.Article in journal (Refereed) Published
Abstract [en]

Different medical and surgical methods have been tried in attempting to reduce endolymphatic pressure in MΘniΦre's disease. Pressure treatment has a role on the treatment staircase, after pharmacological treatment and before destructive methods. Pressure chamber treatment has shown that some patients respond well to the treatment with diminishing inner ear symptoms and also some hearing improvement. Earlier studies have shown that electrocochlear measurements improve after local pressure treatment in the ear. The present study was a prospective randomized placebo controlled, multicentre clinical trial. 56 patients with active MΘniΦre's disease, age 20-65 years, with a hearing loss of 20-65 dB PTA participated. A total of 31 patients completed 2 weeks use with an active apparatus (Meniett) and 25 patients completed the 2 weeks with the placebo gadget. Both machines were produced by Pascal Medical, Halmstad, Sweden. Two weeks before the start of treatment a grommet was placed in the tympanic membrane. A significant improvement concerning frequency and intensity of vertigo, dizziness, aural pressure and tinnitus was reported by the active group on the visual analogue scales (VAS) questionnaire. In the placebo group no change was the most common finding, followed by worsening of the symptoms and a few improvements. The function in professional and family life improved during active treatment and did not during placebo treatment. Pure-tone audiometry did not improve after placebo treatment, but improved at the frequencies 500 Hz and 1,000 Hz after active treatment. The study showed an improvement in the inner ear symptoms after Meniett treatment. The mechanism may be explained by the influence on the round window membrane pressure receptors or an endolymphatic flow out through the pressure release points, such as the endolymphatic duct and sac, thus activating the longitudinal flow. Other mechanisms are also possible.

Place, publisher, year, edition, pages
2000. no 543, 99-101 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-27623Local ID: 12357OAI: oai:DiVA.org:liu-27623DiVA: diva2:248175
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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Ödkvist, LarsArlinger, StigBillermark, Erica

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Faculty of Health SciencesOto-Rhiono-Laryngology and Head & Neck SurgeryÖNH - Öron- Näsa- HalsklinikenTechnical Audiology
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Acta oto-laryngologica. Supplementum
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