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Early effect of parathyroid hormone (1-34) on implant fixation
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2001 (English)In: Clinical Orthopaedics and Related Research, ISSN 0009-921X, no 392, 427-432 p.Article in journal (Refereed) Published
Abstract [en]

Intermittent systemic administration of parathyroid hormone increases bone formation by stimulating osteoblastic activity. The current study determined how parathyroid hormone (1-34) administration influences the bony fixation of stainless steel screws with time. A screw was implanted in the left tibia and a metal rod was implanted in the right tibia in 30 adult male rats that then were injected three times a week with human parathyroid hormone (1-34) at 60 ╡g/kg/injection (n = 15) or saline (n = 15). The animals were euthanized after 1, 2, or 4 weeks of treatment. Eight additional rats received only the screw and were euthanized immediately after implantation. No significant effects of parathyroid hormone on body weight change or ash weight of the femurs were seen. The degree of fixation was assessed by measuring pullout strength of the screws. The mean pullout strength immediately after implantation was 12 N. The pullout strength of the group injected with saline was 33 N after 1 week, 23 N after 2 weeks, and 41 N after 4 weeks. The pullout strength of the group injected with parathyroid hormone increased to 43 N after 1 week, 58 N after 2 weeks, and 100 N after 4 weeks. The increase at 2 and 4 weeks was statistically significant. Strength reflects the mechanical properties of the bone within the screw threads. The contralateral tibia with its metal rod was used for blinded histologic assessment. Parathyroid hormone increased the fraction of the metal surface having contract with bone without an intervening soft tissue layer from 45% to 69% after 1 week. The current results suggest that intermittent parathyroid hormone treatment can enhance early implant fixation by enhancing the density of the surrounding bone and by increasing the implant bone contact.

Place, publisher, year, edition, pages
2001. no 392, 427-432 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27637Local ID: 12373OAI: diva2:248189
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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