Improved healing of transected rabbit Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2
2003 (English)In: American Journal of Sports Medicine, ISSN 0363-5465, Vol. 31, no 4, 555-559 p.Article in journal (Refereed) Published
Background: Achilles tendon ruptures in humans might be treated more efficiently with the help of a growth factor. Cartilage-derived morphogenetic protein-2 has been shown to induce formation of tendon-like tissue. Hypothesis: Cartilage-derived morphogenetic protein-2 has a positive effect on mechanical parameters for tendon healing in a rabbit model with Achilles tendon transection. Study Design: Controlled laboratory study. Methods: The right Achilles tendon of 40 rabbits was transected without tendon suture. Cartilage-derived morphogenetic protein-2 (10 ╡g) or vehicle control (acetate buffer) was injected locally 2 hours postoperatively. All tendons were tested biomechanically at 8 and 14 days, and treated tendons were histologically and radiographically evaluated at 56 days. Results: At 14 days, both failure load and stiffness of treated tendons were increased by 35%. The treated tendons had significantly larger callus size at 8 and 14 days. Histologic and radiographic examination showed no signs of ossification in the treated tendons after 56 days. Conclusions: A single injection of cartilage-derived morphogenetic protein-2 led to a stronger and stiffer tendon callus than that in the controls without inducing bone formation. Clinical Relevance: Similar results from a larger animal model would suggest a possible future use of cartilage-derived morphogenetic protein-2 in the treatment of human Achilles tendon ruptures. ⌐ 2003 American Orthopaedic Society for Sports Medicine.
Place, publisher, year, edition, pages
2003. Vol. 31, no 4, 555-559 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-27644Local ID: 12380OAI: oai:DiVA.org:liu-27644DiVA: diva2:248196