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Systemic alendronate prevents resorption of necrotic bone duringrevascularization. A bone chamber study in rats
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2002 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, Vol. 3Article in journal (Refereed) Published
Abstract [en]

Background: Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new bone has formed or consolidated enough for loadbearing. Bone resorption can be reduced by bisphosphonates. If resorption of the necrotic bone could be reduced during the revascularization phase until sufficient new bone has formed, it would appear that structural failure could be avoided. Methods: To test whether resorption of necrotic bone can be prevented, structural grafts were subjected to new bone ingrowth during systemic bisphosphonate treatment in a rat model. Results: In rats treated with alendronate the necrotic bone was not resorbed, whereas it was almost entirely resorbed in the controls. Conclusion: Systemic alendronate treatment prevents resorption of necrotic bone during revascularization. In patients with osteonecrosis, bisphosphonates may therefore prevent collapse of the necrotic bone.

Place, publisher, year, edition, pages
2002. Vol. 3
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27648DOI: 10.1186/1471-2474-3-1Local ID: 12384OAI: diva2:248200
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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BMC Musculoskeletal Disorders
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