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Bismuth-induced lysosomal rupture in J774 cells
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology.
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2002 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, Vol. 110, no 5, 396-402 p.Article in journal (Refereed) Published
Abstract [en]

Bismuth-containing drugs have several applications, one being their use against Helicobacter pylori-associated peptic ulcers, and bismuth has been discovered in macrophages at the base and margins of peptic ulcers. In the present study, the autometallographic technique for the histochemical demonstration of bismuth was applied, showing that bismuth citrate-exposed J774 cells accumulate the metal in their lysosomes. Such accumulations resulted in lysosomal rupture - assayed by the acridine orange uptake technique and flow cytofluorometry - and ensuing apoptotic cell death.

Place, publisher, year, edition, pages
2002. Vol. 110, no 5, 396-402 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27713DOI: 10.1034/j.1600-0463.2002.100505.xLocal ID: 12451OAI: diva2:248265
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Zhao, MingBrunk, Ulf
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Faculty of Health SciencesPathologyDepartment of Clinical Pathology and Clinical Genetics
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