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Immunolocalization of types I, II, and X collagen in the tibial insertion sites of the medial meniscus
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2000 (English)In: Knee Surgery, Sports Traumatology, Arthroscopy, ISSN 0942-2056, Vol. 8, no 1, 61-65 p.Article in journal (Refereed) Published
Abstract [en]

The medial meniscus of the rabbit knee joint attaches to the tibial plateau via anterior and posterior insertions. Intact meniscal tibial insertions are essential for meniscal function. In the present study the distributions of types I, II, and X collagen in meniscal tibial insertions were investigated by indirect immunohistochemistry in a rabbit model. Four tissue zones were histologically identified in the anterior insertion site, including the ligamentous zone, uncalcified and calcified fibrocartilaginous zones and bone, the ligamentous zone was not observed in the posterior insertion site. Labeling for type I collagen was found to be strong in the ligament tissue and bone, and weak in the fibrocartilages which were also labeled for type II collagen. Tissues positive for different types of collagen overlapped and formed an irregular interface with various angles and depths, especially at the interface between the calcified fibrocartilage and bone. Positive labeling for type X collagen was identified only in the calcified fibrocartilage zone. The coexistence of types I and II collagen in the meniscal tibial insertions may indicate that this structural unit is subjected to both compressive and tensile loads. Type X collagen may play a role in maintaining the calcifying status of this tissue zone, so that its mechanical stiffness is kept between that of uncalcified fibrocartilage and hard bone. Restoration of the insertional structure including the distinct collagen distribution should be considered for a functional meniscal substitution.

Place, publisher, year, edition, pages
2000. Vol. 8, no 1, 61-65 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27758Local ID: 12503OAI: diva2:248310
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-14

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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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Knee Surgery, Sports Traumatology, Arthroscopy
Medical and Health Sciences

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