Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers
2003 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, Vol. 27, no 1, 179-184 p.Article in journal (Refereed) Published
This study investigated the effects of continuous slow infusion of cholecystokinin tetrapeptide (CCK-4), a neuropeptide with panicogenic properties, on functional hemispheric differences, as indexed by quantitative electroencephalographic (EEG) asymmetry and coherence measures. Twenty-four adult volunteers (15 females and 9 males) were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel-group design, with EEG being recorded before and during (10 and 40 min) a 60-min infusion period. No significant treatment differences were observed for absolute EEG power but, compared to placebo, CCK-4 infusion increased asymmetry and reduced coherence of slow-wave activity at midtemporal recording sites. These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD).
Place, publisher, year, edition, pages
2003. Vol. 27, no 1, 179-184 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-27795DOI: 10.1016/S0278-5846(02)00350-0Local ID: 12542OAI: oai:DiVA.org:liu-27795DiVA: diva2:248347