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Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers
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2003 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, Vol. 27, no 1, 179-184 p.Article in journal (Refereed) Published
Abstract [en]

This study investigated the effects of continuous slow infusion of cholecystokinin tetrapeptide (CCK-4), a neuropeptide with panicogenic properties, on functional hemispheric differences, as indexed by quantitative electroencephalographic (EEG) asymmetry and coherence measures. Twenty-four adult volunteers (15 females and 9 males) were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel-group design, with EEG being recorded before and during (10 and 40 min) a 60-min infusion period. No significant treatment differences were observed for absolute EEG power but, compared to placebo, CCK-4 infusion increased asymmetry and reduced coherence of slow-wave activity at midtemporal recording sites. These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD).

Place, publisher, year, edition, pages
2003. Vol. 27, no 1, 179-184 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27795DOI: 10.1016/S0278-5846(02)00350-0Local ID: 12542OAI: diva2:248347
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Gunnarsson, Tove
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Faculty of Health SciencesPsychiatryDepartment of Psychiatry
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Progress in Neuro-psychopharmacology and Biological Psychiatry
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