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Cholecystokinin peptides in cerebrospinal fluid: a pilot study in hypothyroid patients
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry. Linköping University, Faculty of Health Sciences.
Department of Internal Medicine, Karolinska Institute, Huddinge Hospital, Sweden.
Department of Internal Medicine, Karolinska Institute, Huddinge Hospital, Sweden.
Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Linköping University, Faculty of Health Sciences.
1999 (English)In: Human Psychopharmacology: Clinical and Experimental, ISSN 0885-6222, E-ISSN 1099-1077, Vol. 14, no 2, 113-117 p.Article in journal (Refereed) Published
Abstract [en]

The cholecystokinin tetrapeptide (CCK-4) and the sulphated octapeptide (CCK-8) were measured in cerebrospinal fluid obtained from nine hypothyroid patients before and during L-thyroxine treatment. Before treatment, CCK-4 and CCK-8S correlated negatively with S-TSH, whereas CCK-8S also showed a positive correlation with S-T3. During treatment, S-T4 correlated negatively with CCK-8S. CSF collection time was significantly shorter during treatment than prior to treatment for the first (0–6 ml) CSF fraction. On taking CSF collection time into account, the levels of both CCK-4 and CCK-8S in the first CSF fraction were significantly increased during medication. Our results are consistent with an impact of the hypothyroid disorder and L-thyroxine treatment on the disposition of CCK compounds in CSF. This might be due to an altered CSF circulation, but other mechanisms (e.g. metabolism or elimination) cannot be ruled out.

Place, publisher, year, edition, pages
1999. Vol. 14, no 2, 113-117 p.
Keyword [en]
hypothyroidism, cholecystokinin, cerebrospinal fluid, CSF collection time, atmospheric pressure
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-27798DOI: 10.1002/(SICI)1099-1077(199903)14:2<113::AID-HUP76>3.0.CO;2-ALocal ID: 12545OAI: oai:DiVA.org:liu-27798DiVA: diva2:248350
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-08-14Bibliographically approved
In thesis
1. On the cerebrospinal fluid disposition and neurobiological role of cholecystokinin in man
Open this publication in new window or tab >>On the cerebrospinal fluid disposition and neurobiological role of cholecystokinin in man
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cholecystokinin (CCK) is the most abundant neuropeptide in the brain, where it acts as a neurotransmitter and neuromodulator. The tetrapeptide CCK-4 and the octapeptide CCK-8 have been implicated in various behavioural and physiological functions, such as anxiety, pain and satiety. Analyses of the levels of CCK in plasma, CSF and brain tissue have been used in studies aimed at elucidating the pathophysiological mechanisms in psychiatric disorders, but the results have been inconsistent.

Cerebrospinal fluid (CSF) levels of CCK-4 and CCK-8S were analysed in three groups of healthy subjects lumbar-punctured under different conditions, with the aim to provide reference values for studies on patients, and to investigate putative confounding factors. It was found that the concentrations of CCK-4 and CCK-8S were influenced by age, bedrest or not prior to lumbar puncture, neuraxis distance, position during lumbar puncture, height, atmospheric pressure and storage time. For a correct interpretation of data, these factors should be taken into account in future CSF studies in volunteers and patients.

Hypothyroidism is associated with depression. Thyroid hormones have been assumed to affect neuronal functions in the CNS, and animal experiments have indicated a relationship between thyroid hormones and CCK. Depressive symptoms were assessed in hypothyroid patients who were also lumbar-punctured before and during L-thyroxine treatment. Thyroid stimulating hormone, tri-iodothyronine and thyroxine in serum correlated with both CCK peptides in the CSF. A negative correlation between CCK-4 and inner tension (anxiety) was found.

Various studies implicate the involvement of brain-stem structures in the aetiology of panic attacks. Brain-stem auditory evoked potentials were recorded in healthy subjects before and during infusion with the panic-provoking agent CCK-4 or placebo. CCK-4 delayed the latencies of peak I, III and V, and decreased peak III amplitude. This suggests that exogenous CCK-4 affects stimulus processing in the brain stem.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2000. 70 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 643
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28039 (URN)12800 (Local ID)91-7219-744-7 (ISBN)12800 (Archive number)12800 (OAI)
Public defence
2000-10-20, Berzeliussalen, Hälsouniversitetet, Linköping, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2012-08-14Bibliographically approved

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Gunnarsson, ToveNordin, Conny

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