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Effect of carbon dioxide on cochlear blood flow in guinea pigs
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
2000 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 120, no 1, 11-18 p.Article in journal (Refereed) Published
Abstract [en]

The influence of carbon dioxide (CO2) on cochlear blood flow (CBF), blood pressure (SBP) and skin blood flow (SBF) was studied in anaesthetized guinea pigs. A transient acute respiratory acidosis was produced by inhalation of CO2 and oxygen (O2) gas mixtures. The blood flows were measured by laser Doppler flowmetry (LDF). High CO2 increased CBF and SBP, and decreased SBF in a dose-dependent manner. The responses of CBF, SBP and SBF to high CO2 were reversible. Our results indicate that high CO2 (and low pH) dilates the smooth muscle of the blood vessels, resulting in an increase in CBF. CO2 also activates the sympathetic nervous system in the whole body, producing an increase in SBP. The distribution of alpha- adrenergic fibres/receptors is abundant in skin and scarce in the cochlea. The constrictive effect on blood vessels is much greater in the skin than in the cochlea, thus our results showed a decrease in SBF during stimulation with higher CO2.

Place, publisher, year, edition, pages
2000. Vol. 120, no 1, 11-18 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-27856Local ID: 12615OAI: oai:DiVA.org:liu-27856DiVA: diva2:248408
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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Lundquist, Per-Gotthard

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Faculty of Health SciencesOto-Rhiono-Laryngology and Head & Neck SurgeryÖNH - Öron- Näsa- Halskliniken
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Acta Oto-Laryngologica
Medical and Health Sciences

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CiteExportLink to record
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  • Other style
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  • de-DE
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  • en-US
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  • nn-NB
  • sv-SE
  • Other locale
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  • html
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