Caudate nucleus dopamine D2 receptors in vascular dementia
2002 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, Vol. 14, no 1, 22-25 p.Article in journal (Refereed) Published
Caudate nucleus dopamine (DA) D2 receptors were studied in patients with vascular dementia (VaD) and in a control group using [3H]raclopride as a radioligand. There was no significant difference in the number of DA D2 receptors in the VaD group as compared with controls. The binding affinity was significantly lower in the VaD group. When the VaD group was subdivided into subjects with or without neuroleptic treatment, there were no differences in the numbers of receptors as compared with controls, and the significant differences in binding affinity remained for both VaD subgroups. The present results are discussed with reference to the previous finding of a reduced density of caudate nucleus DA uptake sites in the same VaD group and to results from studies on DA D2 receptors in Alzheimer's disease and Parkinson's disease. Copyright ⌐ 2002 S. Karger AG, Basel.
Place, publisher, year, edition, pages
2002. Vol. 14, no 1, 22-25 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-27876DOI: 10.1159/000058329Local ID: 12636OAI: oai:DiVA.org:liu-27876DiVA: diva2:248428