Gaba transporters (GAT-1) in Alzheimer´s disease.
1999 (English)In: Journal of neural transmission, ISSN 0300-9564, Vol. 106, no 11-12, 1141-1149 p.Article in journal (Refereed) Published
The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [H-3]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [H-3]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.
Place, publisher, year, edition, pages
1999. Vol. 106, no 11-12, 1141-1149 p.
GAT-1, GABA transporters, Alzheimer's disease
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-27879Local ID: 12639OAI: oai:DiVA.org:liu-27879DiVA: diva2:248431