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Increased [3H]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Geriatrics. Östergötlands Läns Landsting, MC - Medicincentrum, Geriatrik-LAH.
2002 (English)In: Neuropsychobiology, ISSN 0302-282X, Vol. 45, no 1Article in journal (Refereed) Published
Abstract [en]

Postmortem samples from individuals with schizophrenia (n = 13) and control subjects (n = 10) were investigated for binding of [3H]tiagabine to GABA transporter-1 GAT-1. The binding was analyzed in the cingulate cortex and the caudate nucleus. There were no differences in binding affinity between the groups in any of the investigated areas. The maximum number of binding sites (Bmax) was elevated in the schizophrenic cingulate cortex compared to controls (1,264 ▒ 96 vs. 860 ▒ 123 fmol/mg of protein). The Bmax in the caudate nucleus for schizophrenics (426 ▒ 40 fmol/mg of protein) was the same as for controls (495 ▒ 69 fmol/mg of protein). The increase in GAT-1 in schizophrenia could be explained by a modulatory upregulation in the cingulate cortex. Copyright ⌐ 2002 S. Karger AG, Basel.

Place, publisher, year, edition, pages
2002. Vol. 45, no 1
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27883DOI: 10.1159/000048666Local ID: 12643OAI: diva2:248435
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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