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CSF collection time at lumbar puncture is influenced by plasma cholesterol and triglycerides
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
2001 (English)In: Neuropsychobiology, ISSN 0302-282X, Vol. 43, no 1, 19-22 p.Article in journal (Refereed) Published
Abstract [en]

It is a fairly well-known fact that the CSF collection time (tapping time) at lumbar puncture may influence CSF levels of monoamine compounds (e.g. the serotonin metabolite 5-hydroxyindoleacetic acid, 5-HIAA) and some neuropeptides. Since serum levels of cholesterol and triglycerides and low CSF levels of 5-HIAA have been linked to violent behaviour and impulsivity, we investigated retrospectively whether serum cholesterol and triglycerides affect CSF collection time. The series consists of 14 healthy males lumbar punctured at the L4-5 level. We found that both serum cholesterol and serum triglycerides influenced the CSF collection time for 12 ml of CSF (R = 0.77, p = 0.0067). There was no correlation between cholesterol in serum and CSF, nor between cholesterol in the CSF and collection time. However, we accidentally found a correlation between cholesterol in the CSF and age. The proposed hypothesis tries to explain why cholesterol- and triglyceride-rich lipoprotein particles modify the CSF collection time and influence endothelial function with a subsequent effect on CSF production and/or intraspinal pressure. Thus, it may be of interest to pay attention to serum cholesterol and triglycerides, their effect on CSF collection time and, in the next step, their putative impact on levels of various compounds in the CSF. Copyright ⌐ 2001 S. Karger AG, Basel.

Place, publisher, year, edition, pages
2001. Vol. 43, no 1, 19-22 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27906DOI: 10.1159/000054860Local ID: 12666OAI: diva2:248458
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

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Nordin, Conny
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