liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Intraspinal pressure influences CSF disposition of tryptophan and 5-HIAA
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
2001 (English)In: Neuropsychobiology, ISSN 0302-282X, Vol. 44, no 2, 84-87 p.Article in journal (Refereed) Published
Abstract [en]

Cerebrospinal fluid (CSF) concentrations of monoamine compounds are influenced by factors such as age, gender, height, body weight, tapping time, and atmospheric pressure. We have now examined the role of intraspinal pressure. Thirteen male volunteers underwent lumbar puncture in the right decubitus position without preceding strict bed rest. The intraspinal pressure was recorded, and monoamine precursors, transmitters, and metabolites were analyzed in two consecutively collected CSF fractions. Tryptophan in 12 ml of CSF and the 5-hydroxyindoleacetic acid concentration ratio [fraction II (7-12 ml CSF)/fraction I (0-6 ml CSF)] correlated with the intraspinal pressure. Hypothetically, the intraspinal pressure may be a confounding factor for a correct interpretation of CSF tryptophan and 5-hydroxyindoleacetic acid concentrations, and this is an issue that has to be addressed in future CSF studies. Copyright ⌐ 2001 S. Karger AG, Basel.

Place, publisher, year, edition, pages
2001. Vol. 44, no 2, 84-87 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27908DOI: 10.1159/000054921Local ID: 12668OAI: diva2:248460
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Nordin, Conny
By organisation
Faculty of Health SciencesPsychiatryDepartment of Psychiatry
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 26 hits
ReferencesLink to record
Permanent link

Direct link