liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
CSF taurine level is influenced by plasma cholesterol and the CYP2D6 phenotype
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
KI .
KI .
Show others and affiliations
2003 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, Vol. 13, no 5, 333-335 p.Article in journal (Refereed) Published
Abstract [en]

Eight healthy male volunteers, lumbar-punctured before and during simvastatin treatment, were phenotyped for CYP2D6 analysis of the debrisoquine metabolic ratio (the ratio between the urinary recovery of debrisoquine and its 4-hydroxy metabolite) after a single oral dose of debrisoquine. The mean cerebrospinal fluid concentrations of cholesterol and taurine did not differ before and during treatment. During (but not before) treatment taurine in the CSF correlated with the debrisoquine metabolic ratio (r=-0.93, P=0.0007) Our results might indicate an influence of CYP2D6 on the level of taurine in the CSF that was secondary to the change in plasma cholesterol. ⌐ 2003 Elsevier B.V./ECNP. All rights reserved.

Place, publisher, year, edition, pages
2003. Vol. 13, no 5, 333-335 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-27912DOI: 10.1016/S0924-977X(03)00033-6Local ID: 12672OAI: diva2:248464
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Nordin, Conny
By organisation
Faculty of Health SciencesPsychiatryDepartment of Psychiatry
In the same journal
European Neuropsychopharmacology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 37 hits
ReferencesLink to record
Permanent link

Direct link