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CSF taurine level is influenced by plasma cholesterol and the CYP2D6 phenotype
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Uppsala.
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2003 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, E-ISSN 1873-7862, Vol. 13, no 5, 333-335 p.Article in journal (Refereed) Published
Abstract [en]

Eight healthy male volunteers, lumbar-punctured before and during simvastatin treatment, were phenotyped for CYP2D6 analysis of the debrisoquine metabolic ratio (the ratio between the urinary recovery of debrisoquine and its 4-hydroxy metabolite) after a single oral dose of debrisoquine. The mean cerebrospinal fluid concentrations of cholesterol and taurine did not differ before and during treatment. During (but not before) treatment taurine in the CSF correlated with the debrisoquine metabolic ratio (r=-0.93, P=0.0007) Our results might indicate an influence of CYP2D6 on the level of taurine in the CSF that was secondary to the change in plasma cholesterol. ⌐ 2003 Elsevier B.V./ECNP. All rights reserved.

Place, publisher, year, edition, pages
2003. Vol. 13, no 5, 333-335 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-27912DOI: 10.1016/S0924-977X(03)00033-6Local ID: 12672OAI: oai:DiVA.org:liu-27912DiVA: diva2:248464
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13

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