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Prevalence of symptoms possibly related to PADAM, in a Swedish population aged 55, 65 and 75 years
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine.
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2005 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 50, no 3, 161-166 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: With age there is an average decline in the concentration of biologically active testosterone. It is still controversial if this leads to a clinically relevant deficit, "partial androgen deficiency of the ageing man" (PADAM). Our objective was to investigate the prevalence of a series of symptoms possibly associated with PADAM in an assumed normal-population of older men. Methods: We developed a questionnaire including items about symptoms possibly associated with PADAM as well as background data covering demography, medical history, mood status, medication, castration therapy, as well as smoking, exercise and alcohol habits. The 10 items of the ADAM-questionnaire, designed to predict low bio-available T, were also included. The questionnaire was sent to all 1885 men 55, 65 or 75-years-old, living in Linköping, Sweden. Results: We identified a number of symptoms that differed significantly (P<0.01) between age groups, e.g., "increased abdominal circumference", "decrease in muscle strength and/or endurance", "decreased libido", "less strong erection" and "lack of energy". From factorial analysis we found that the symptoms co-varied in four different groups. Conclusion: The prevalence of a number of symptoms differed significantly between age groups, but we cannot infer that there is a causal connection between an average age-dependent decline in testosterone function and these symptoms. There are several other ways to interpret these results like the existence of concurrent somatic and/or mood disorders or ageing as such. For this purpose further studies including measurements of testosterone concentrations relating to the findings of this study have to be performed. © 2004 Elsevier Ireland Ltd. All rights reserved.

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2005. Vol. 50, no 3, 161-166 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-28783DOI: 10.1016/j.maturitas.2004.05.008Local ID: 13967OAI: oai:DiVA.org:liu-28783DiVA: diva2:249595
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Gladh, MathiasRahgozar, MohammadHammar, MatsFredrikson, MatsSpetz, Anna-Clara

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Faculty of Health SciencesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingOccupational and Environmental Medicine
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